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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MECP2 All Species: 22.73
Human Site: S349 Identified Species: 62.5
UniProt: P51608 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51608 NP_001104262.1 486 52441 S349 P G R K S K E S S P K G R S S
Chimpanzee Pan troglodytes XP_521333 638 67833 S501 P G R K S K E S S P K G R S S
Rhesus Macaque Macaca mulatta XP_001088566 619 66078 S482 P G R K S K E S S P K G R S S
Dog Lupus familis XP_853488 486 52281 S349 P G R K S K E S S P K G R S S
Cat Felis silvestris
Mouse Mus musculus Q9Z2D6 484 52289 S349 P G R K S K E S S P K G R S S
Rat Rattus norvegicus Q00566 492 53029 S349 P G R K S K E S S P K G R S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508704 393 42162 Q262 K E E E T D P Q A V P K K R G
Chicken Gallus gallus
Frog Xenopus laevis NP_001081854 467 51739 Q335 I E K V M K G Q N P A K S P E
Zebra Danio Brachydanio rerio NP_997901 524 57133 A374 P S R K H K E A D P G S S S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 75.8 78.1 96.5 N.A. 95.2 94.3 N.A. 65.2 N.A. 65.6 50.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 76.1 78.5 97.5 N.A. 96.5 95.9 N.A. 71.1 N.A. 75 62.9 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 N.A. 13.3 53.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 26.6 N.A. 26.6 60 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 12 12 0 12 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 12 0 0 12 0 0 0 0 0 0 % D
% Glu: 0 23 12 12 0 0 78 0 0 0 0 0 0 0 12 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 67 0 0 0 0 12 0 0 0 12 67 0 0 12 % G
% His: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 12 0 12 78 0 89 0 0 0 0 67 23 12 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % N
% Pro: 78 0 0 0 0 0 12 0 0 89 12 0 0 12 0 % P
% Gln: 0 0 0 0 0 0 0 23 0 0 0 0 0 0 0 % Q
% Arg: 0 0 78 0 0 0 0 0 0 0 0 0 67 12 0 % R
% Ser: 0 12 0 0 67 0 0 67 67 0 0 12 23 78 78 % S
% Thr: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 12 0 0 0 0 0 12 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _